Initiated several basic research projects on asymmetric synthesis of complex natural products. 

• Macrolides (Jaspamide, Geodemolide, Rhizoxin, Rifamycin)
  
• Anti-HIV agents (Calanolides, AZT, Batzellidine)
  
• Immunosuppressants (FK – 506, Cyclosporin, Rapamycin, ISP-I)
  
• Glycopeptides & Cyclic peptides (Vancomycin, K-13)
  
• Peptides (Andrimid)
  
• b -Lactam (Thienamycin & 1b -methylthienamycin)
  
• Hydroxy unsaturated fatty acids (Leukotrienes, dimorphecolic acid)
  
• Anti-cancer (Sesbanimide, aureolic acids) cervinomycins.

Initiated projects on rationale design of new drugs

• HIV Protease inhibitors with Abbott Laboratories
  
• New anti-HIV and anti-cancer lead molecules with NCI, USA

Developed several drug technologies for Indian Pharmaceutical Industries

• Flurbiprofen (anti-inflammatory, FDC)
  
• Norfloxacin (anti-bacterial, CIPLA)
  
• Ciprofloxacin (anti-bacterial, CIPLA)
  
• Gemfibrozil (cholesterol lowering agent-Cadila Labs)
  
• Omeprazole (anti-ulcer-CIPLA, Dai-Ichi Karkaria)
  
• Sultamicillin (anti-bacterial-Torrent)
  
• Sulbactam (anti-bacterial-Torrent)
  
• Astemizole (anti-histaminic-Cadila labs)
  
• Ketorolac (anti-bacterial-CIPLA, Lupin)
  
• Etoposide (anticancer-CIPLA)
  
• AZT (anti-AIDS, CIPLA)
  
• ‘S’ – Timolol (Anti-glaucoma, FDC)
  
• Stavudine (anti-glaucome, FDC)
  
• Enalapril 9antihypertensive, Neuland Labs., & Cadila)
  
• Metoprolol & Nadolol (b -blockers, Lupin)
  
• Rifapentine (Anti-Tb, Lupin)
  
• Azithromycin (antibacterial, Torrent Labs., Kopran)
  
• Cisapride (antihistaminic, Kopran)
  
• Acyclovir (antiviral, Wockhardt)
  
• Felodepin (antihypertensive, Cadila)

Initiated multi-disciplinary projects

• CFC Substitutes with Sriram and Navin Fluoride
  
• Cyanuric Chloride with ATIC
  
• CO based chemicals with Lupin Laboratories
  
• Established CAD Facility for providing basic designs for chemical plants.
  

Deputy Director & Head
Division of Organic Chemistry II
National Chemical Laboratory
Pune 411 008    (1980-85)

Initiated basic research projects of biologically active components

• Anti-cancer compounds (adriamycin, Daunomycin, Fredericamycin, Lavendamycin)
  
• Macrolides (Recifeiolide, Rifamycin, Zaralinone)
  
• Hydroxy Fatty Acids (a -Lipoic acid, Coreolic acid, dimorphecolic acid)
  
• Biotin

Developed several drugs technologies for Indian industries

• Vincristine (anti-cancer agent, CIPLA)
  
• Vinblastine (anti-cancer agent, CIPLA)
  
• Ibuprofen (analgesic- CIPLA)
  
• Sulfamethoxazole (anti-bacterial, CIPLA)
  
• Diazepam, Chlordeazepoxide (antianxiety agents-Centaur)
  
• Vitamin B6 (lupin Laboratories)
  
• Mebendazole (anthelminthic-CIPLA)
  
• Salbutamol, Terbutaline (antiasthematic – CIPLA)

Harvard University
USA   (1975-77)

• Worked as a Research Associate with Prof. E.J Corey on the synthesis of maytansine.

Scientist & Project Leader
National Chemical Laboratory
Pune 411 008   (1965-79).

• Chemistry of natural products of plants, inserts and dyes. Isolated more than 100 new natural products which resulted in more than 70 publications in the area of natural products.

Research Fellow (CSIR)
National Chemical Laboratory
Pune 411 008   (1960-65).

• Worked with Prof. K. Venkataraman, Director and an eminent scientist at the National Chemical Laboratory, Pune and obtained the Ph.D (Tech) degree in 1964 from the Bombay University.

Active Consultant to several Indian Drug & pharmaceutical and Chemical Industries.

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